Wednesday, 13 August 2008

Saccharomyces cerevisiae: Human and Yeast Eukaryote RNA Polymerase Subunits

Species: cerevisiae (and toy) (from latin, 'of beer')
Genus: Saccharomyces (from latin, 'sugar mold')
Family: Saccharomycetaceae
Order: Saccharomycetales
Class: Saccharomycetes
Subphylum: Saccharomycotina
Phylum: Ascomycota

Also known as Brewer's Yeast, Ale Yeast, Baker's Yeast, Budding Yeast
This species is the main source of nutritional yeast and yeast extract.
It is estimated that yeast shares 23% of its genome with that of humans.

Saccharomycetes is the most studied of the yeasts due to its availability and its being around for thousands of years...

Six Human RNA Polymerase Subunits Functionally Substitute for Their Yeast Counterparts
(view PDF at American Society of Microbiology)

McKune, Keith; Moore, Paul A.; Hull, Melissa W.; Woychik, Nancy A.

This study looks at Saccharomyces cerevisiae pol II

"Immunoprecipitation of the cell extracts from yeast cells containing either of the human subunits that function in place of their yeast counterparts in vivo suggested that they assemble with the complete set of yeast RNA polymerase II subunits. Overall, a total of six of the seven human subunits tested previously or in this study are able to substitute for their yeast counterparts in vivo, underscoring the remarkable similarities between the transcriptional machineries of lower and higher eukaryotes."

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